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Samantha Marie Marquez

Celloidosomes® The Bioengineering of Artificial Glands & Bioreactors

Midlothian, VA
Grade 10, Maggie L. Walker Governor’s School

marquez

Celloidosomes® The Bioengineering of Artificial Glands & Bioreactors

Samantha Marquez has designed and fabricated 3D organized cell structures, called Celloidosomes®. By definition, the Celloidosome® is a “living capsule” with a biomembrane shell (tissue/biofilm) and a core that acts as a container/reservoir. Novel microfluidic protocols were used as platforms to engineer multiple-emulsion templates and direct the cell assembly onto liq-liq, liq-gas, or liq-gel interfaces. This new paradigm in cell architecture enables the design and engineering of biological structures based on a “bottom-up strategy”. These systems are ideal models for Bio-microreactors, Artificial Micro-Glands, and Tissue Engineering. Evidence was provided for the unique functionality of the Celloidosome® structure with key examples: 1) Celloidosomes® as tissue building blocks (NIH-3T3 fibroblasts) without necrosis during tissue formation, in addition to a proof of concept demonstrating a novel artificial microgland (HepG2) @ NIH 3T3 Celloidosome®, and 2) using chemotaxis and electrostatic driving forces, Bacteria and Yeast Celloidosomes® were bioengineered (3D biofilm microbag) with applications in water treatment, Biosensing, Bioremediation, Bioconversion, and selective extraction of radioactive heavy metals. For the first time, evidence is shown of two-cell, two-layer Celloidosome®: a unique symbiotic cooperation between algae and bacteria to create a hybrid-Celloiodosome®.

 

RADIO INTERVIEW ABOUT SAMANTHA

 

   
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The National Gallery for America's Young Inventors ™ is the only nationally recognized hall of fame for student inventors, established in 1993 and given permission by the adult National Inventors Hall of Fame Board in Washington, D.C. to archive and enshrine great student inventions and inventors K-12.


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